Abstract | OBJECTIVES: METHODS: RESULTS: The 28-day uncorrected adequate clinical and parasitological response (ACPR) was 69.0%, with 15.5% Late Clinical Failure and 15.5% Late Parasitologic Failure rates. The PCR-corrected 28-day ACPR was 90.2%. Clinical risk factors for recurrent infection (recrudescences and reinfections) were lower axillary temperature at enrollment and low weight-for-age Z-score. The presence of single nucleotide polymorphisms pfcrt 76T and pfmdr1 86Y at baseline was associated with increased risk of recurrent infections, both reinfections and recrudescences. CONCLUSION:
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Authors | J I Thwing, C O Odero, F O Odhiambo, K O Otieno, S Kariuki, R Ord, C Roper, M McMorrow, J Vulule, L Slutsker, R D Newman, M J Hamel, M Desai |
Journal | Tropical medicine & international health : TM & IH
(Trop Med Int Health)
Vol. 14
Issue 3
Pg. 294-300
(Mar 2009)
ISSN: 1365-3156 [Electronic] England |
PMID | 19187521
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Artemisinins
- Drug Combinations
- Mdr1 protein, Plasmodium falciparum
- Membrane Transport Proteins
- Multidrug Resistance-Associated Proteins
- PfCRT protein, Plasmodium falciparum
- Protozoan Proteins
- amodiaquine, artesunate drug combination
- Amodiaquine
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Topics |
- Amodiaquine
(adverse effects, therapeutic use)
- Animals
- Antimalarials
(adverse effects, therapeutic use)
- Artemisinins
(adverse effects, therapeutic use)
- Child, Preschool
- Drug Combinations
- Drug Resistance
- Female
- Follow-Up Studies
- Humans
- Infant
- Malaria, Falciparum
(drug therapy, parasitology)
- Male
- Membrane Transport Proteins
(genetics)
- Multidrug Resistance-Associated Proteins
(genetics)
- Plasmodium falciparum
(drug effects, genetics)
- Polymorphism, Single Nucleotide
- Protozoan Proteins
(genetics)
- Recurrence
- Treatment Outcome
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