Abstract | AIMS: To determine the ability of probiotic lactobacilli to improve the treatment of vulvovaginal candidiasis (VVC) using a randomized, double-blind and placebo-controlled trial. METHODS AND RESULTS: Fifty-five women diagnosed with VVC by vaginal discharge positive for Candida spp. (according to culture method) associated with at least one of the symptoms ( itching and burning vaginal feeling, dyspareunia and dysuria), were treated with single dose of fluconazole (150 mg) supplemented every morning for the following 4 weeks with two placebo or two probiotic capsules (containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14). At 4 weeks, the probiotic treated group showed significantly less vaginal discharge associated with any of the above mentioned symptoms (10.3%vs 34.6%; P = 0.03) and lower presence of yeast detected by culture (10.3%vs 38.5%; P = 0.014). CONCLUSION: This study has shown that probiotic lactobacilli can increase the effectiveness of an anti-fungal pharmaceutical agent in curing disease. SIGNIFICANCE AND IMPACT OF THE STUDY: This novel finding of probiotic lactobacilli augmenting the cure rate of yeast vaginitis, not only offers an alternative approach to a highly prevalent condition that adversely affects the quality of life of women around the world, but also raises the question of how this combination works.
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Authors | R C R Martinez, S A Franceschini, M C Patta, S M Quintana, R C Candido, J C Ferreira, E C P De Martinis, G Reid |
Journal | Letters in applied microbiology
(Lett Appl Microbiol)
Vol. 48
Issue 3
Pg. 269-74
(Mar 2009)
ISSN: 1472-765X [Electronic] England |
PMID | 19187507
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Fluconazole
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Topics |
- Adolescent
- Adult
- Antifungal Agents
(administration & dosage, therapeutic use)
- Candida
(classification, drug effects, isolation & purification)
- Candidiasis, Vulvovaginal
(drug therapy, microbiology, therapy)
- Double-Blind Method
- Female
- Fluconazole
(administration & dosage, therapeutic use)
- Humans
- Limosilactobacillus reuteri
- Lacticaseibacillus rhamnosus
- Middle Aged
- Probiotics
(administration & dosage, therapeutic use)
- Treatment Outcome
- Young Adult
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