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[Effect of capsule of Shenshuai Yangzhen on malnutrition rats with chronic renal failure by 5/6 nephrectomy].

AbstractOBJECTIVE:
To investigate the effects of capsule of Shenshuai Yangzhen, a preparation of traditional Chinese medicine, on malnutrition rats with chronic renal failure (CRF).
METHODS:
SD rats received 5/6 nephrectomy for preparation of CRF models, and fed 4% casein at the same time. Observed when malnutrition began. Those consistents with malnutrition of CRF condition were randomized into model control group, Ketosteril group, Shenshuai Yangzhen group, and normal control group. After 4-weeks treatment as indicated, The blood parameters, like blood serum albumin (ALB), type-1 insulin like growth factor (IGF-1), total cholesterol (TC), triglyeride (TG), urea nitrogen (BUN), serum creatinine (Scr), haemoglobin (Hb), 24 hour urineprotein (24hUpr) and weight were determined. Nephrotic tissue was observed by microscope (included HE and PAS).
RESULTS:
Malnutrition situation in CRF rats began at the end of 10-weeks. After 4-weeks treatment, weight in Shenshuai Yangzhen group were higher significantly (P < 0.05). Compared with model control group, blood serum BUN (P < 0.05), SCr (P < 0. 05) and 24h Upr (P < 0.001) in Shenshuai Yangzhen group were significantly lower with substantially elevated blood serum ALB, Hb, IGF-1 (P < 0.01; P < 0.001; P < 0.001, respectively). Pathology of Shenshuai Yangzhen group was a meliorated significantly after treated.
CONCLUSION:
Capsule of Shenshuai Yangzhen has a possible therapic effect on improving malnutrition in rats with renal insufficiency.
AuthorsLian-Bo Wei, Cong Deng, Jie-Bin Chen, Yu-Ming Li, Li-Wen Huang, Chun-Shui Gong
JournalZhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 31 Issue 9 Pg. 1391-5 (Sep 2008) ISSN: 1001-4454 [Print] China
PMID19180967 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Capsules
  • Drug Combinations
  • Drugs, Chinese Herbal
  • Hemoglobins
  • Serum Albumin
  • Triglycerides
  • Cholesterol
  • Creatinine
Topics
  • Animals
  • Blood Urea Nitrogen
  • Capsules
  • Cholesterol (blood)
  • Creatinine (blood)
  • Drug Combinations
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Hemoglobins (analysis)
  • Kidney (pathology)
  • Kidney Failure, Chronic (complications)
  • Male
  • Malnutrition (blood, drug therapy, etiology)
  • Nephrectomy
  • Phytotherapy
  • Plants, Medicinal (chemistry)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Serum Albumin (analysis)
  • Triglycerides (blood)

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