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PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.

AbstractOBJECTIVE:
The Ala allele of the Pro12Ala polymorphism (rs1801282) of peroxisome proliferator-activated receptor gamma (PPARgamma) is protective against type 2 diabetes (T2DM). Resistin, secreted from adipocytes, causes insulin resistance in rodents. Resistin gene expression is reduced by the PPARgamma ligand. We previously reported that subjects with the G/G genotype of a resistin gene single nucleotide polymorphism (SNP) at -420 (rs1862513) had the highest circulating resistin levels, followed by C/G and C/C. The aim of this study was to determine the relationship among PPARgamma Pro12Ala polymorphism, resistin SNP-420, and plasma resistin.
DESIGN, PATIENTS AND MEASUREMENTS:
We cross-sectionally analysed 2077 community-dwelling subjects attending an annual medical check-up. Genotypes were determined by TaqMan analysis. Fasting plasma resistin was measured using ELISA.
RESULTS:
Plasma resistin appeared to be higher in subjects with the Pro/Pro genotype of PPARgamma than those with Pro/Ala and Ala/Ala genotypes (mean +/- SE, 11.6 +/- 0.2 vs. 10.4 +/- 0.5 microg/l). Multiple regression analysis, adjusted for age, gender, BMI, and resistin SNP-420, revealed that the Pro/Pro genotype was a positive predictor of plasma resistin (PPARgamma , Pro/Pro vs. Pro/Ala + Ala/Ala, unstandardized regression coefficient (beta) = 1.03, P = 0.0384). The effects of the Pro/Pro genotype of PPARgamma (Pro/Pro vs. Pro/Ala + Ala/Ala) and the G/G genotype of resistin SNP-420 (G/G vs. C/C) on plasma resistin were synergistic (beta = 4.76, P = 0.011).
CONCLUSIONS:
The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes were synergistically associated with plasma resistin, when adjusted for age, gender, and BMI, in the Japanese general population.
AuthorsHaruhiko Osawa, Yasuharu Tabara, Ryuichi Kawamoto, Jun Ohashi, Masaaki Ochi, Hiroshi Onuma, Wataru Nishida, Kazuya Yamada, Jun Nakura, Tetsuro Miki, Hideichi Makino, Katsuhiko Kohara
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 71 Issue 3 Pg. 341-5 (Sep 2009) ISSN: 1365-2265 [Electronic] England
PMID19178525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • PPAR gamma
  • Resistin
Topics
  • Aged
  • Asian Continental Ancestry Group (genetics)
  • Cross-Sectional Studies
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mutation, Missense
  • PPAR gamma (genetics)
  • Polymorphism, Single Nucleotide
  • Resistin (blood, genetics)

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