Abstract | OBJECTIVE: DESIGN, PATIENTS AND MEASUREMENTS: We cross-sectionally analysed 2077 community-dwelling subjects attending an annual medical check-up. Genotypes were determined by TaqMan analysis. Fasting plasma resistin was measured using ELISA. RESULTS: Plasma resistin appeared to be higher in subjects with the Pro/Pro genotype of PPARgamma than those with Pro/Ala and Ala/Ala genotypes (mean +/- SE, 11.6 +/- 0.2 vs. 10.4 +/- 0.5 microg/l). Multiple regression analysis, adjusted for age, gender, BMI, and resistin SNP-420, revealed that the Pro/Pro genotype was a positive predictor of plasma resistin ( PPARgamma , Pro/Pro vs. Pro/ Ala + Ala/Ala, unstandardized regression coefficient (beta) = 1.03, P = 0.0384). The effects of the Pro/Pro genotype of PPARgamma ( Pro/Pro vs. Pro/ Ala + Ala/Ala) and the G/G genotype of resistin SNP-420 (G/G vs. C/C) on plasma resistin were synergistic (beta = 4.76, P = 0.011). CONCLUSIONS: The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes were synergistically associated with plasma resistin, when adjusted for age, gender, and BMI, in the Japanese general population.
|
Authors | Haruhiko Osawa, Yasuharu Tabara, Ryuichi Kawamoto, Jun Ohashi, Masaaki Ochi, Hiroshi Onuma, Wataru Nishida, Kazuya Yamada, Jun Nakura, Tetsuro Miki, Hideichi Makino, Katsuhiko Kohara |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 71
Issue 3
Pg. 341-5
(Sep 2009)
ISSN: 1365-2265 [Electronic] England |
PMID | 19178525
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Aged
- Asian People
(genetics)
- Cross-Sectional Studies
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Mutation, Missense
- PPAR gamma
(genetics)
- Polymorphism, Single Nucleotide
- Resistin
(blood, genetics)
|