Abstract | BACKGROUND: METHODS: Between 1982 and 2007, 37 065 dermatitis patients were tested with Fragrance mix I. Those who were positive were tested for individual fragrance allergy. Chemicals were categorized according to whether their exposure pattern was solely cutaneous, oral or mixed. Current and past atopic dermatitis rates were compared between the whole population and groups allergic to individual fragrances. Age and gender were controlled. RESULTS:
Cinnamic alcohol and cinnamal allergy groups had reduced rates of both 'current' [24/266 (9.0%) P = 0.0008, 38/364 (10.4%) P = 0.0005] and 'past' atopic dermatitis [44/266 (16.5%) P = 0.009, 70/346 (19.2%) P = 0.037]. Atopic dermatitis rates in groups allergic to Evernia prunastri and hydroxycitronellal (cutaneous exposure only) were not reduced [120/597 (20.1%) and 41/153 (26.8%)]. Groups allergic to cinnamic alcohol (P < 0.0001, P < 0.0001) and cinnamal (P < 0.0001, P < 0.004) had reductions in 'current' and 'past' atopic dermatitis, compared with Evernia prunastri. CONCLUSIONS:
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Authors | J M L White, I R White, I Kimber, D A Basketter, D A Buckley, J P McFadden |
Journal | Allergy
(Allergy)
Vol. 64
Issue 2
Pg. 312-6
(Feb 2009)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 19178409
(Publication Type: Journal Article)
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Chemical References |
- Allergens
- Haptens
- Perfume
|
Topics |
- Adult
- Allergens
(immunology)
- Dermatitis, Allergic Contact
(complications, etiology)
- Dermatitis, Atopic
(complications, epidemiology)
- Female
- Haptens
(immunology)
- Humans
- Male
- Middle Aged
- Perfume
(adverse effects, chemistry)
- Retrospective Studies
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