Demonstration of 1-year duration of immunity for attenuated Bordetella bronchiseptica vaccines in dogs.

Abstract	Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus (CPI), and canine adenovirus type 2 (CAV-2) were used in this study. One group was vaccinated with a single dose of monovalent attenuated Bb vaccine and one group with a trivalent vaccine containing attenuated Bb, CPI, and CAV-2; dogs were vaccinated intranasally with a single dose of the respective vaccines. The third group served as unvaccinated controls. All vaccinated dogs subsequently developed serum antibody titers to Bb that persisted for at least 1 year. Following Bb challenge 1 year after vaccination, all vaccinated dogs, regardless of group, showed significantly fewer clinical signs and shed significantly fewer challenge organisms than unvaccinated controls. These results demonstrate that intranasal administration of a single dose of monovalent attenuated Bb vaccine or trivalent vaccine containing attenuated Bb, CPI, and CAV-2 provides 1 year of protection against Bb.
Authors	Craig Lehar, Huchappa Jayappa, Jason Erskine, Alicia Brown, Diane Sweeney, Terri Wassmoen
Journal	Veterinary therapeutics : research in applied veterinary medicine (Vet Ther) Vol. 9 Issue 4 Pg. 257-62 ( 2008) ISSN: 1528-3593 [Print] United States
PMID	19177330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Bacterial Antibodies, Viral Bacterial Vaccines Parainfluenza Vaccines Vaccines, Attenuated Viral Vaccines
Topics	Adenoviridae Infections (prevention & control, veterinary) Adenoviruses, Canine (immunology) Administration, Intranasal Animals Animals, Newborn Antibodies, Bacterial (blood) Antibodies, Viral (blood) Bacterial Vaccines (administration & dosage) Bordetella Infections (prevention & control, veterinary) Bordetella bronchiseptica (immunology) Dog Diseases (prevention & control) Dogs Female Male Parainfluenza Vaccines (administration & dosage) Parainfluenza Virus 2, Human (immunology) Random Allocation Rubulavirus Infections (prevention & control, veterinary) Vaccines, Attenuated Viral Vaccines (administration & dosage)

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