A new compound, brefeldin A formylate, from Penicillium sp. strain HLKG-44.

Abstract

A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC(50) value of 18.9 microg/ml by the MTT assay protocol.

• Authors: Han-Wen Zhang, Hong-Ming Cheng, Hua Fang, Yu-Fen Zhao, Mei-Juan Fang
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 11 Issue 1 Pg. 54-7 ( 2009) ISSN: 1477-2213 [Electronic] England
• PMID: 19177238 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• brefeldin A formylate
• Brefeldin A
• Ergosterol

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Brefeldin A (analogs & derivatives, chemistry, isolation & purification)
• Crystallography, X-Ray
• Drug Screening Assays, Antitumor
• Ergosterol (chemistry, isolation & purification)
• Humans
• Molecular Conformation
• Molecular Structure
• Penicillium (chemistry)