Abstract |
Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of human epilepsy, and it is often resistant to conventional antiepileptic drug (AED) therapy. Here we tested whether a single intrahippocampal administration of the synaptic blocker botulinum neurotoxin E (BoNT/E) is effective in reducing spontaneous recurrent seizures (SRS) in a mouse model of MTLE. Unilateral intrahippocampal injection of kainic acid (KA) in mice was used as a model of MTLE. Electroencephalography (EEG) recordings of SRS were performed during the chronic phase of epilepsy, before and after administration of either BoNT/E or vehicle. Frequency of SRS was significantly decreased for at least 5 days following BoNT/E, but not vehicle, infusion. Our findings demonstrate that BoNT/E can effectively reduce seizure incidence in a mouse model of MTLE.
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Authors | Flavia Antonucci, Yuri Bozzi, Matteo Caleo |
Journal | Epilepsia
(Epilepsia)
Vol. 50
Issue 4
Pg. 963-6
(Apr 2009)
ISSN: 1528-1167 [Electronic] United States |
PMID | 19175393
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Dyskinesia Agents
- Botulinum Toxins
- Kainic Acid
- botulinum toxin type E
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Topics |
- Analysis of Variance
- Animals
- Anti-Dyskinesia Agents
(therapeutic use)
- Botulinum Toxins
(therapeutic use)
- Disease Models, Animal
- Electroencephalography
(methods)
- Epilepsy, Temporal Lobe
(chemically induced, drug therapy, pathology)
- Hippocampus
(drug effects)
- Kainic Acid
- Male
- Mice
- Mice, Inbred C57BL
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