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[Therapy of progressive scleroderma with gamma-interferon].

Abstract
In an open study conducted over 6 months, gamma interferon was administered to 12 patients suffering from progressive systemic sclerosis. The dosage used was three injections, each of 50 micrograms s.c. in the first 2 weeks, followed by 50 micrograms twice a week. All patients fulfilled the criteria required for classification as type II in the ADF system or the major criterion of the ARA (proximal sclerosis). Therapeutic effects were noted as a decrease in of skin thickness (10/12 = 83%), improvement in muscle and joint pains (5/8 = 63%) and reduction of the procollagen-type III peptide in serum by more than 20% (8/12 = 66%). No effects on fibrosis or dysfunction of internal organs were seen. Disease progression did not occur in any of the patients. Side-effects of gamma interferon were noted in 4 patients, in the form of slightly elevated body temperature and transient influenza-like symptoms, but these occurred only at the beginning of therapy and soon passed.
AuthorsH Mensing
JournalDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 42 Issue 6 Pg. 380-3 (Jun 1991) ISSN: 0017-8470 [Print] Germany
Vernacular TitleTherapie der progressiven Sklerodermie mit gamma-Interferon.
PMID1917461 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Autoantibodies
  • Peptide Fragments
  • Procollagen
  • procollagen Type III-N-terminal peptide
  • Interferon-gamma
Topics
  • Adult
  • Aged
  • Autoantibodies (analysis)
  • Drug Administration Schedule
  • Female
  • Humans
  • Injections, Subcutaneous
  • Interferon-gamma (administration & dosage, adverse effects)
  • Male
  • Middle Aged
  • Peptide Fragments (blood)
  • Procollagen (blood)
  • Scleroderma, Systemic (immunology, therapy)

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