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[Role of c-c chemokines in the determination of pleural effusion etiology].

AbstractUNLABELLED:
The purpose of the study was to evaluate predictive value of vascular endothelial growth factor (VEGF) in the differential diagnosis of pleural effusion.
MATERIAL AND METHODS:
By Light's criteria in 29 cases exudates and 10 transudates was recognized. We investigated 39 patients with pleural effusion (congestive heart failure--10, parapneumonic--11, tuberculous--6, malignant--12, transudate--10).
RESULTS:
The mean VEGF value were significantly higher (p = 0.002) in the effusion of lung cancer patient (3958.33 pg/ml) than in the serum (1030.33 pg/ml). The mean VEGF levels were significantly higher (p = 0.004) in patient with exudates (2711.10 pg/ml) than in transudates (683 pg/ml). Based on the receiver operating characteristic (ROC) curve analysis, cut off value in differentiation of exudates and transudates was accepted at the level of 560 pg/ml (sensitivity 80% and specificity 70%). The mean VEGF levels were significantly higher (p = 0.008) in the malignant effusion (3958.33 pg/ml) than in the tuberculous effusion (1308.90 pg/ml). Based on the ROC curve analysis, cut off value in differentiation of malignant and tuberculous effusion was accepted at the level of 2000 pg/ml (sensitivity 92% and specificity 83%). The positive correlation between pleural VEGF concentrations and pleural lactate dehydrogenase (LDH) level were observed (r = 0.67, p < 0.05).
CONCLUSION:
We conclude that pleural effusion VEGF level could be useful in the differentiation between exudates and transudate and also between malignant and tuberculous exudates.
AuthorsMarzena Trzaska-Sobczak, Władysław Pierzchała, Grzegorz Brozek, Małgorzata Farnik
JournalWiadomosci lekarskie (Warsaw, Poland : 1960) (Wiad Lek) Vol. 61 Issue 7-9 Pg. 190-4 ( 2008) ISSN: 0043-5147 [Print] Poland
Vernacular TitleOcena przydatności naczyniowo-śródbłonkowego czynnika wzrostu w diagnostyce płynu opłucnowego.
PMID19172830 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Chemokines, CC
  • Vascular Endothelial Growth Factor A
Topics
  • Aged
  • Biomarkers, Tumor (analysis)
  • Chemokines, CC (analysis)
  • Enzyme-Linked Immunosorbent Assay
  • Exudates and Transudates (chemistry)
  • Female
  • Heart Failure (metabolism)
  • Humans
  • Male
  • Middle Aged
  • Pleural Effusion (chemistry)
  • Pleural Effusion, Malignant (metabolism)
  • Pneumonia (metabolism)
  • ROC Curve
  • Tuberculosis, Pleural (metabolism)
  • Vascular Endothelial Growth Factor A (analysis)

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