We analyzed associations among OGG1 Ser326Cys and MUTYH Gln324His gene polymorphisms in relation to
lung cancer risk using PCR-RFLP. The study involved 108
lung cancer patients and 121 non-
cancer controls divided into non-smokers, smokers according to pack-years smoked in Japanese.
RESULTS: The results showed that the MUTYH
His/His genotype compared with Gln/Gln genotype showed an increased risk for
lung cancer (adjusted odds ratio [OR] 3.03, confidence interval [95%CI], 1.31-7.00, p = 0.010), whereas there was no significant increase for the Gln/His genotype (adjusted OR 1.35, 95%CI 0.70-2.61, p = 0.376). The MUTYH
His/His genotype was at a borderline increased risk for both
adenocarcinoma and
squamous cell carcinoma (adjusted OR 2.50, 95%CI 0.95-6.62, p = 0.065 for
adenocarcinoma; adjusted OR 3.20, 95%CI 0.89-11.49, p = 0.075 for
squamous cell carcinoma, respectively). However, the OGG1 Ser/Cys or
Cys/Cys genotypes compared with the Ser/Ser genotype did not have significantly increased risk for
lung cancer, containing either
adenocarcinoma or
squamous cell carcinoma. The joint effect of tobacco exposure and the MUTYH
His/His genotype compared with the Gln/Gln genotype showed a significant association with
lung cancer risk in smokers, and there was not significantly increased in non-smokers (adjusted OR 3.82, 95%CI 1.22-12.00, p = 0.022 for smokers; adjusted OR 2.60, 95%CI 0.60-11.25, p = 0.200 for non-smokers, respectively). The effect of tobacco exposure and the OGG1 Ser326Cys showed also no significant risk for
lung cancer.
CONCLUSION: