Abstract | BACKGROUND: OBJECTIVES: METHODS: Twelve postmenopausal diabetic women with vulvar lichen simplex chronicus were enrolled in this trial. Each patient was treated with pimecrolimus 1% cream which was applied twice daily in a thin layer to the vulvae for 3 months. Clinical examination and recording of patients' symptoms using a scoring system was performed by the same physician before, after 4 weeks and after 3 months of therapy. RESULTS: All of the patients completed the study. A substantial decrease in pruritus after treatment was reported by the patients at the 4th week (2.17+/-0.72, p<0.01) and 3rd month of treatment (0.42+/-0.92, p<0.001) when compared with the baseline score (3.75+/-0.45). Follow-up of the patients after 3 months of treatment showed that complete cure occurred in 10 patients (83.3%) and the pruritus was improved in two (16.7%) patients. CONCLUSIONS:
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Authors | Handan Kiymet Kelekci, Hikmet Gulsen Uncu, Bulent Yilmaz, Orcun Ozdemir, Necdet Sut, Sefa Kelekci |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 19
Issue 5
Pg. 274-8
( 2008)
ISSN: 0954-6634 [Print] England |
PMID | 19160532
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Dermatologic Agents
- pimecrolimus
- Tacrolimus
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Topics |
- Adult
- Aged
- Dermatologic Agents
(therapeutic use)
- Diabetes Complications
(complications)
- Female
- Humans
- Middle Aged
- Neurodermatitis
(complications, drug therapy)
- Postmenopause
- Prospective Studies
- Pruritus Vulvae
(complications, drug therapy)
- Tacrolimus
(analogs & derivatives, therapeutic use)
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