| Abstract | Pseudomembranous colitis (PMC) is known to be associated with the administration of antibiotics which alter normal gastrointestinal flora and allow overgrowth of Clostridium difficile. Most cases of rifampicin-induced PMC are seen in patients with pulmonary tuberculosis, but not with gastrointestinal tuberculosis. We report a case of PMC associated with rifampicin therapy in a patient with gastrointestinal tuberculosis. A 65-year-old female patient with rectal cancer and gastrointestinal tuberculosis was admitted due to abdominal pain and diarrhea. She was treated with anti-tuberculosis agents containing rifampicin. On colonoscopic examination, mucoid exudates and yellowish plaque lesions were observed. Anti-tuberculosis agents were stopped, and the patient was treated with metronidazole. Symptoms were relieved and did not recur when all the anti-tuberculosis agents except rifampicin were started again. When a patient complains of abdominal pain or diarrhea while taking rifampicin, the physician should consider the possibility of rifampicin-associated PMC. |
| Authors | Yong Jun Choi, Hyung Gil Kim, Yun Ah Choi, Woo Chul Joo, Dong Wook Son, Chul Hyun Kim, Yong Woon Shin, Young Soo Kim
(Affiliation: Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.)
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| Journal | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
(Korean J Gastroenterol)
Vol. 53
Issue 1
Pg. 53-6
(Jan 2009)
ISSN: 1598-9992 Korea (South) |
| PMID | 19158472
(Publication Type: English Abstract, Journal Article)
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