Abstract | OBJECTIVE: PATIENTS AND METHODS: Overall 197 patients were admitted to nine medical and surgical intensive care units (ICUs) at a 2200-bed university hospital during a 3-month period. Retrospectively, the patients were split into three groups: group A comprised 24 patients with proven invasive fungal infections admitted for a median of 40 days. Group B comprised 58 patients who were admitted to the ICU for 30 days but without fungal infection. One hundred and fifteen post-operative patients served as controls (group C). The levels of (1,3)-beta-D-glucan were monitored in all patients twice weekly during their ICU admittance. RESULTS: Average (1,3)-beta-D-glucan concentrations were significantly higher in the patients with fungal infections compared to group B and group C (median 44 vs. 22 and 12.9 pg/ml, respectively; p<0.001). For a serum (1,3)-beta-D-glucan level of 40 pg/ml, the sensitivity, the specificity, the positive predictive value, the negative predictive value, the area under the curve of the receiver operating characteristics (AUC ROC) curve, the likelihood ratio (LR)+ and LR- were 52.2, 75.9, 46.2, 80, 0.7, 2.16, and 0.63, respectively, on day 7. Patients in group A had bacterial infections significantly more often than patients in group B (p=0.003). The hospitalization before ICU admittance for group A was significantly longer than for groups B and C (median 19 (group A) vs. 6 (group B) vs. 10 (group C) days; p<0.05). CONCLUSIONS:
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Authors | Elisabeth Presterl, Bernhard Parschalk, Edith Bauer, Andrea Lassnigg, Stefan Hajdu, Wolfgang Graninger |
Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
(Int J Infect Dis)
Vol. 13
Issue 6
Pg. 707-12
(Nov 2009)
ISSN: 1878-3511 [Electronic] Canada |
PMID | 19157947
(Publication Type: Journal Article)
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Chemical References |
- Proteoglycans
- beta-Glucans
- polysaccharide-K
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Topics |
- Aspergillosis
(diagnosis, epidemiology, microbiology, mortality)
- Aspergillus
(classification, isolation & purification)
- Candida
(classification, isolation & purification)
- Candidiasis
(diagnosis, epidemiology, microbiology, mortality)
- Female
- Humans
- Incidence
- Intensive Care Units
(statistics & numerical data)
- Length of Stay
(statistics & numerical data)
- Male
- Mycoses
(diagnosis, epidemiology, microbiology, mortality)
- Predictive Value of Tests
- Proteoglycans
- beta-Glucans
(blood)
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