[Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy].

Abstract

Leg ulcers may result in serious morbidity in patients with connective tissue diseases and Raynaud's phenomenon (RP). We describe a 35-year-old woman with mixed connective tissue disease who suffered from leg ulcers refractory to iloprost. When the patient was treated with the selective endothelin A receptor antagonist sitaxsentan for pulmonary arterial hypertension, the ulcers improved within 4 weeks and resolved completely thereafter. In addition, severity of RP ameliorated markedly. Further evaluation of sitaxsentan in patients with connective tissue diseases suffering from ischemic skin ulcers is required.

• Authors: H Becker, C Sunderkoetter, P Willeke, W Domschke, M Gaubitz, M Mohr
• Journal: Zeitschrift fur Rheumatologie (Z Rheumatol) Vol. 68 Issue 2 Pg. 154-6 (Mar 2009) ISSN: 1435-1250 [Electronic] Germany
• Vernacular Title: Unterschenkelulzera bei Sharp-Syndrom. Abheilung unter Sitaxentan.
• PMID: 19156432 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antihypertensive Agents
• Isoxazoles
• Thiophenes
• sitaxsentan

Topics

• Adult
• Antihypertensive Agents (administration & dosage)
• Female
• Humans
• Isoxazoles (administration & dosage)
• Leg Ulcer (complications, drug therapy)
• Raynaud Disease (complications, drug therapy)
• Scleroderma, Systemic (complications, drug therapy)
• Thiophenes (administration & dosage)
• Treatment Outcome