Abstract |
Three cross-linked polyacrylate polymers containing either methylenebis-acrylamide (MBA), trimethylolpropane triacrylate ( TMPTA), or triallylamine (TAA) cross-linkers were tested for genotoxicity with the Salmonella mammalian microsome assay, the L5178Y mouse lymphoma TK +/- assay, the unscheduled DNA synthesis assay in primary cultures of rat hepatocytes, and the in vivo bone marrow cytogenetic assay. The results indicate that none of the three polymers was genotoxic in these assays.
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Authors | E D Thompson, J L Seymour, M J Aardema, R A LeBoeuf, B L Evans, D B Cody |
Journal | Environmental and molecular mutagenesis
(Environ Mol Mutagen)
Vol. 18
Issue 3
Pg. 184-99
( 1991)
ISSN: 0893-6692 [Print] United States |
PMID | 1915313
(Publication Type: Journal Article)
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Chemical References |
- Acrylamides
- Acrylates
- Mutagens
- Polymers
- triallylamine
- Allylamine
- trimethylolpropane triacrylate
- 9,10-Dimethyl-1,2-benzanthracene
- N,N'-methylenebisacrylamide
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(pharmacology)
- Acrylamides
(pharmacology)
- Acrylates
(pharmacology)
- Allylamine
(analogs & derivatives, pharmacology)
- Animals
- Biotransformation
- Bone Marrow
(drug effects, physiology)
- Cells, Cultured
- Chromosome Aberrations
- DNA Replication
(drug effects)
- Leukemia L5178
- Liver
(drug effects, physiology)
- Mice
- Microsomes, Liver
(metabolism)
- Mutagenicity Tests
(methods)
- Mutagens
(pharmacology)
- Polymers
- Rats
- Salmonella typhimurium
(drug effects)
- Tumor Cells, Cultured
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