Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

Abstract

We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).

• Authors: David Meyre, Jérôme Delplanque, Jean-Claude Chèvre, Cécile Lecoeur, Stéphane Lobbens, Sophie Gallina, Emmanuelle Durand, Vincent Vatin, Franck Degraeve, Christine Proença, Stefan Gaget, Antje Körner, Peter Kovacs, Wieland Kiess, Jean Tichet, Michel Marre, Anna-Liisa Hartikainen, Fritz Horber, Natascha Potoczna, Serge Hercberg, Claire Levy-Marchal, François Pattou, Barbara Heude, Maithé Tauber, Mark I McCarthy, Alexandra I F Blakemore, Alexandre Montpetit, Constantin Polychronakos, Jacques Weill, Lachlan J M Coin, Julian Asher, Paul Elliott, Marjo-Riitta Järvelin, Sophie Visvikis-Siest, Beverley Balkau, Rob Sladek, David Balding, Andrew Walley, Christian Dina, Philippe Froguel
• Journal: Nature genetics (Nat Genet) Vol. 41 Issue 2 Pg. 157-9 (Feb 2009) ISSN: 1546-1718 [Electronic] United States
• PMID: 19151714 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• Intracellular Signaling Peptides and Proteins
• MAF protein, human
• MC4R protein, human
• Membrane Glycoproteins
• NPC1 protein, human
• Niemann-Pick C1 Protein
• PTER protein, human
• Proteins
• Proto-Oncogene Proteins c-maf
• Receptor, Melanocortin, Type 4
• Alpha-Ketoglutarate-Dependent Dioxygenase FTO
• FTO protein, human

Topics

• Adult
• Age of Onset
• Alpha-Ketoglutarate-Dependent Dioxygenase FTO
• Carrier Proteins (genetics)
• Case-Control Studies
• Child
• Europe (epidemiology)
• Gene Frequency
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Intracellular Signaling Peptides and Proteins
• Membrane Glycoproteins (genetics)
• Niemann-Pick C1 Protein
• Obesity, Morbid (epidemiology, genetics)
• Polymorphism, Single Nucleotide
• Population
• Proteins (genetics)
• Proto-Oncogene Proteins c-maf (genetics)
• Quantitative Trait Loci
• Receptor, Melanocortin, Type 4 (genetics)
• Risk Factors