Abstract |
The toxic effects of mercuric chloride ( HgCl2), emisan 6 (a methoxy-ethyl mercury fungicide), and methyl mercuric chloride (CH3HgCl) on the adrenocortical-pituitary activity of the catfish were investigated after 45, 90, and 180 days of exposure. The adrenocortical cells were highly stimulated in the 90-day HgCl2 group and became hyperplastic in the 180-day group. These cells were active in the 90-day emisan 6 group, with the infiltration of lymphocytes and fibrosis in the 180-day group. In the 90-day CH3HgCl gropu, the cells were active, with lymphocytic infiltration, fibrosis, and necrotic changes in some areas. In the 180-day CH3HgCl group, there was an extensive infiltration of lymphocytes, with localized sites of necrosis and hyperplasia. The ACTH cells in the pituitary were hypertrophied and degranulated in the Hg-treated groups, suggesting increased secretion of ACTH. The plasma cortisol level decreased significantly in the 90- and 180-day Hg-exposed groups in a time-dependent manner. Of the three mercurials, CH3HgCl is the most toxic in reducing the plasma cortisol level in all durations. These results suggest that Hg impairs the adrenocortical-pituitary activity of the catfish.
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Authors | R Kirubagaran, K P Joy |
Journal | Ecotoxicology and environmental safety
(Ecotoxicol Environ Saf)
Vol. 22
Issue 1
Pg. 36-44
(Aug 1991)
ISSN: 0147-6513 [Print] Netherlands |
PMID | 1914994
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fungicides, Industrial
- Methylmercury Compounds
- neanthine
- Mercuric Chloride
- Ethylmercuric Chloride
- methylmercuric chloride
- Hydrocortisone
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Topics |
- Animals
- Catfishes
- Ethylmercuric Chloride
(analogs & derivatives, toxicity)
- Female
- Fungicides, Industrial
(toxicity)
- Hydrocortisone
(blood)
- Male
- Mercuric Chloride
(toxicity)
- Methylmercury Compounds
(toxicity)
- Pituitary-Adrenal System
(drug effects, pathology)
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