Abstract | AIM: METHODS: In study I, 39 consecutive outpatients (mean age +/- standard deviation, 77 +/- 8 years), who were referred to our memory clinic and were not taking any medications, were studied. They were divided into three groups according to cognitive function on the Hasegawa Dementia Scale-Revised (HDSR): group 1 (n = 8), 28 points or more; group 2 (n = 18), 21-27 points; and group 3 (n = 13), 20 points or less. In study II, 14 outpatients with hypertension and mild cognitive impairment (aged 79 +/- 8 years; HDSR score, 24 +/- 4) were assigned to receive cilnidipine (10-20 mg/day). The control group (n = 10) matched for age, HDSR and blood pressure was followed without cilnidipine. RESULTS: In study I, although age and basal blood pressure were similar among the three groups, the blood pressure response to a mental arithmetic test was twice as large in group 2 (26 +/- 12 mmHg in systolic pressure and 11 +/- 8 mmHg in diastolic pressure) as those in groups 1 and 3. In study II, after 4 weeks, cilnidipine treatment significantly decreased the blood pressure responses to the mental arithmetic test compared to the baseline as well as to those of the control group. CONCLUSIONS:
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Authors | Yumiko Kawashima, Masahiro Akishita, Hiroshi Hasegawa, Koichi Kozaki, Kenji Toba |
Journal | Geriatrics & gerontology international
(Geriatr Gerontol Int)
Vol. 8
Issue 4
Pg. 278-83
(Dec 2008)
ISSN: 1447-0594 [Electronic] Japan |
PMID | 19149840
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Calcium Channel Blockers
- Dihydropyridines
- cilnidipine
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Topics |
- Aged
- Aged, 80 and over
- Calcium Channel Blockers
(therapeutic use)
- Case-Control Studies
- Cognition Disorders
(complications)
- Dihydropyridines
(therapeutic use)
- Humans
- Hypertension
(drug therapy, etiology, psychology)
- Stress, Psychological
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