[Fixed combinations of glaucoma medications].

Abstract	Fixed combinations represent a combination of two ocular hypotensive agents into one single ophthalmic solution. Current commercially available fixed combinations used in glaucoma treatment include Combigan, Cosopt, Xalcom, Duotrav and Ganfort. Statistically significant superiority of the ocular hipotensive efficacy of the fixed combinations vs monotherapy with the two individual constituents is present connected with Cosopt and Xalcom. It also exists vs timolol ophthalmic solution relative to Combigan, Duotrav and Ganfort but is missing within these fixed combinations vs brimonidine, travatan and bimatoprost respectively. A slight reduction, that is clinically and statistically insignificant relative to fixed combination efficacy vs the nonfixed combinations (e.g. concomitant but separate administration of the two individual components) is acceptable when this is balanced by potential benefits of the fixed combinations therapy (improved tolerability and convenience,increased compliance,cost and time economies,decreased washout effect and reduced exposure to preservatives).
Authors	D Călugăru, M Călugăru
Journal	Oftalmologia (Bucharest, Romania : 1990) (Oftalmologia) Vol. 52 Issue 3 Pg. 23-31 ( 2008) ISSN: 1220-0875 [Print] Romania
Vernacular Title	Combinaţii fixe medicamintoase topice în tratamentul glaucomului.
PMID	19149113 (Publication Type: Journal Article, Review)
Chemical References	Amides Antihypertensive Agents Drug Combinations Ophthalmic Solutions Prostaglandins F, Synthetic Quinoxalines Sulfonamides Thiophenes Cloprostenol Brimonidine Tartrate Latanoprost Timolol dorzolamide Bimatoprost Travoprost
Topics	Amides (administration & dosage) Antihypertensive Agents (administration & dosage) Bimatoprost Brimonidine Tartrate Cloprostenol (administration & dosage, analogs & derivatives) Drug Combinations Drug Therapy, Combination Glaucoma (drug therapy, physiopathology) Humans Intraocular Pressure (drug effects) Latanoprost Ophthalmic Solutions (administration & dosage) Prostaglandins F, Synthetic (administration & dosage) Quinoxalines (administration & dosage) Sulfonamides (administration & dosage) Thiophenes (administration & dosage) Timolol (administration & dosage) Travoprost Treatment Outcome

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