Abstract | AIMS: METHODS AND RESULTS: In this multinational registry, 5093 STEMI patients received a stent: 1313 (26%) a DES and 3780 (74%) only BMS. Groups differed in baseline characteristics, type, or timing of percutaneous coronary intervention, with a higher baseline risk for patients receiving BMS. Two-year follow-up was available in 55 and 60% of the eligible BMS and DES patients, respectively. Unadjusted mortality was lower during hospitalization, similar for the first 6 months after discharge, and higher from 6 months to 2 years, for DES patients compared with that of BMS patients. Overall, unadjusted 2-year mortality was 5.3 vs. 3.9% for BMS vs. DES patients (P = 0.04). In propensity- and risk-adjusted survival analyses (Cox model), post-discharge mortality was not different up to 6 months (P = 0.21) or 1 year (P = 0.34). Late post-discharge mortality was higher in DES patients from 6 months to 2 years (HR 4.90, P = 0.01) or from 1 to 2 years (HR 7.06, P = 0.02). Similar results were observed when factoring in hospital mortality. CONCLUSION: The observation of increased late mortality with DES vs. BMS suggests that DES should probably be avoided in STEMI, until more long-term data become available.
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Authors | Ph Gabriel Steg, Keith A A Fox, Kim A Eagle, Mark Furman, Frans Van de Werf, Gilles Montalescot, Shaun G Goodman, Alvaro Avezum, Wei Huang, Joel M Gore, Global Registry of Acute Coronary Events (GRACE) Investigators |
Journal | European heart journal
(Eur Heart J)
Vol. 30
Issue 3
Pg. 321-9
(Feb 2009)
ISSN: 1522-9645 [Electronic] England |
PMID | 19147604
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
(instrumentation, mortality)
- Contraindications
- Drug-Eluting Stents
(adverse effects, statistics & numerical data)
- Electrocardiography
- Epidemiologic Methods
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(mortality, physiopathology, therapy)
- Stents
(adverse effects, statistics & numerical data)
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