Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin?

Abstract

Hair follicle tumors show a broad range of phenotypic variability and diverse histopathological characteristics. To date, different genes and signalling cascades have been implicated in the development and growth of these tumors including the sonic hedgehog, nuclear factor kappa-B and wingless pathway. While the former three have received ample attention, little is known about the possible role of mammalian target of rapamycin (mTOR) in trichofollicular tumorigenesis. Here, we delineate how mTOR can link the various signalling pathways, thereby proposing a unifying model for hair follicle tumor formation.

• Authors: Maurice A M van Steensel, Michel van Geel, Sadhanna Badeloe, Pamela Poblete-Gutiérrez, Jorge Frank
• Journal: Experimental dermatology (Exp Dermatol) Vol. 18 Issue 2 Pg. 185-91 (Feb 2009) ISSN: 1600-0625 [Electronic] Denmark
• PMID: 19146581 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hedgehog Proteins
• NF-kappa B
• Wnt Proteins
• Protein Kinases
• MTOR protein, human
• TOR Serine-Threonine Kinases

Topics

• Hair Follicle
• Hedgehog Proteins (physiology)
• Humans
• NF-kappa B (physiology)
• Protein Kinases (physiology)
• Signal Transduction (physiology)
• Skin Neoplasms (physiopathology)
• TOR Serine-Threonine Kinases
• Wnt Proteins (physiology)