Abstract | OBJECTIVE: METHODS: RESULTS: In vivo, alphastatin was sufficiently potent to suppress nude mice neovascularization. Daily administration of alphastatin produced significant tumor growth suppression [ tumor volume:(612.65+/-23.45) microm(3),(1145.96+/-29.89) microm(3) vs(1771+/-31.05) microm(3) (P<0.05), tumor weight: (0.31+/-0.03) g, (0.12+/-0.02) g vs (0.67+/-0.02) g (P<0.05)]. Immunohistochemical studies of tumor tissues revealed decreased microvessel density in alphastatin-treated animals as compared with controls. Alphastatin significantly inhibited tumor endothelial cells SPK activity. CONCLUSION:
Alphastatin shows potent antiangiogenic properties in nude mice,which might be closely associated with down-regulation of tumor endothelial cells SPK activity.
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Authors | Tao Li, Ling Chen |
Journal | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
(Zhonghua Wei Chang Wai Ke Za Zhi)
Vol. 12
Issue 1
Pg. 61-4
(Jan 2009)
ISSN: 1671-0274 [Print] China |
PMID | 19145507
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- alphastatin
- Fibrinogen
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Topics |
- Angiogenesis Inhibitors
(pharmacology, therapeutic use)
- Animals
- Cell Line, Tumor
- Fibrinogen
(pharmacology, therapeutic use)
- Humans
- Mice
- Mice, Nude
- Neovascularization, Pathologic
(prevention & control)
- Stomach Neoplasms
(blood supply, pathology)
- Xenograft Model Antitumor Assays
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