The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds.

Abstract

Clinical and morphological comparison of wound healing after transplantation of living cultured allofibroblast on days 1-2 after the injury, collagen-1-based dressing with PDGF-BB, and traditional dressing with levomecol ointment showed that bioactive dressing accelerated wound epithelialization (5-7 days vs. 20-22 days with gauze dressing); the incidence of suppurative complications decreased, no crust formed, and epithelialization was not associated with the formation of a hypertrophic cicatrix. Biological dressing based on living cultured allofibroblasts and collagen-1 with PDGF-BB exhibited equal stimulatory effects on burn wound healing.

• Authors: A S Ermolov, S V Smirnov, V B Khvatov, L P Istranov, O I Koniushko, E G Kolokolchikova, M V Sychevsky, V S Bocharova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 146 Issue 1 Pg. 153-7 (Jul 2008) ISSN: 0007-4888 [Print] United States
• PMID: 19145375 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Platelet-Derived Growth Factor
• Proto-Oncogene Proteins c-sis
• Becaplermin

Topics

• Becaplermin
• Biological Dressings
• Burns (pathology, therapy)
• Cell Transplantation
• Cells, Cultured
• Epithelium (pathology, physiology)
• Female
• Fibroblasts (cytology)
• Humans
• Male
• Platelet-Derived Growth Factor (therapeutic use)
• Proto-Oncogene Proteins c-sis
• Regeneration (physiology)
• Wound Healing