Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia.

Abstract

Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 microg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 microg/kg simvastatin, p<0.05).

• Authors: Yu I Ragino, V A Vavilin, N F Salakhutdinov, S I Makarova, E M Stakhneva, O G Safronova, V V Lyakhovich, Yu P Nikitin, G A Tolstikov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 146 Issue 2 Pg. 206-9 (Aug 2008) ISSN: 0007-4888 [Print] United States
• PMID: 19145319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Antioxidants
• Endothelin-1
• simvaglyzin
• von Willebrand Factor
• Glycyrrhizic Acid
• Cholesterol
• Simvastatin
• Aryldialkylphosphatase
• Nitrous Oxide

Topics

• Analysis of Variance
• Animals
• Anticholesteremic Agents (therapeutic use)
• Antioxidants (therapeutic use)
• Aryldialkylphosphatase (blood)
• Cholesterol (blood)
• Diet
• Endothelin-1 (blood)
• Endothelium, Vascular (drug effects)
• Fluorometry
• Glycyrrhizic Acid (therapeutic use)
• Hypercholesterolemia (drug therapy, metabolism)
• Male
• Nitrous Oxide (metabolism)
• Rabbits
• Simvastatin (therapeutic use)
• von Willebrand Factor (metabolism)