Prevention of atrial fibrillation after coronary artery bypass grafting via atrial electromechanical interval and use of amiodarone prophylaxis.

In our previous study, we defined a cut-off point of 120 ms for atrial electromechanical interval (AEMi) to determine the risk of atrial fibrillation (AF) occurrence. Accordingly, the present study sought to investigate whether or not a prophylactic perioperative administration of amiodarone could reduce the incidence of AF in a high-risk group (AEMi >120 ms) undergoing coronary artery bypass grafting (CABG). In this prospective, randomized study, 100 patients with AEMi >120 ms received either amiodarone (n=50) or placebo (n=50). The endpoints were AF occurrence after CABG and hospital and intensive care unit (ICU) lengths of stay after CABG. The incidence of postoperative AF was significantly higher in the placebo group than that of the amiodarone group (88% of patients in control group vs. 16% of patients in amiodarone group, P<0.0001). The prophylactic therapy with amiodarone significantly reduced the ICU length of stay (2.28+/-1.00 vs. 3.60+/-0.90 days, P<0.0001) and hospital length of stay (5.64+/-2.35 vs. 7.78+/-1.46 days, P<0.0001). The incidence of postoperative AF among patients with high AEMi was significantly reduced by a prophylactic amiodarone treatment, resulting in shorter ICU and hospital stays.
AuthorsFarideh Roshanali, Mohammad Hossein Mandegar, Mohammad Ali Yousefnia, Farshid Alaeddini, Bahare Saidi
JournalInteractive cardiovascular and thoracic surgery (Interact Cardiovasc Thorac Surg) Vol. 8 Issue 4 Pg. 421-5 (Apr 2009) ISSN: 1569-9285 [Electronic] England
PMID19144672 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Arrhythmia Agents
  • Amiodarone
  • Aged
  • Amiodarone (administration & dosage)
  • Anti-Arrhythmia Agents (administration & dosage)
  • Atrial Fibrillation (etiology, physiopathology, prevention & control)
  • Atrial Function (drug effects)
  • Coronary Artery Bypass (adverse effects)
  • Double-Blind Method
  • Drug Administration Schedule
  • Echocardiography, Doppler
  • Electrocardiography, Ambulatory
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Intensive Care Units
  • Length of Stay
  • Male
  • Middle Aged
  • Prospective Studies
  • Time Factors
  • Treatment Outcome

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