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Effect of selenium deficiency on the antioxidative status and muscle damage in growing turkeys.

Abstract
An experiment investigated the effect of different selenium supplementations on the antioxidant defence system and on the occurrence of muscle dystrophy in growing turkeys. Newly hatched male turkeys (B.U.T. Big 6) were divided into eight groups of 18 turkeys each and fed either a basal diet (selenium < 0.010 mg/kg diet), or the basal diet supplemented with 0.10; 0.15; 0.20; 0.25; 0.30; 0.35 or 0.40 mg selenium/kg diet in the form of sodium selenate. Vitamin E was adequately supplemented in all diets. After 35 days, muscle damage parameters including aspartate aminotransferase, creatine kinase, creatine kinase M and B were significantly increased in the selenium deficient Group I. A significant reduction of weight gain, feed consumption and selenium dependent glutathione peroxidase activity was also observed in the liver of selenium deficient birds. The ratio of oxidised glutathione (GSSG) to total glutathione (tGSH) was substantially altered in the selenium deficient Group I as well as in Group II (0.10 mg selenium/kg feed). The activity of glutathione reductase (GR) and glutathione-S-transferase (GST) was not affected by selenium deficiency.
AuthorsJulia Fischer, Astrid Bosse, Josef Pallauf
JournalArchives of animal nutrition (Arch Anim Nutr) Vol. 62 Issue 6 Pg. 485-97 (Dec 2008) ISSN: 1745-039X [Print] England
PMID19143231 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Glutathione Peroxidase
  • Glutathione Reductase
  • Glutathione Transferase
  • Aspartate Aminotransferases
  • Creatine Kinase
  • Creatine Kinase, BB Form
  • Creatine Kinase, MM Form
  • Selenium
Topics
  • Animal Feed
  • Animal Nutritional Physiological Phenomena
  • Animals
  • Antioxidants (metabolism)
  • Aspartate Aminotransferases (metabolism)
  • Creatine Kinase (metabolism)
  • Creatine Kinase, BB Form
  • Creatine Kinase, MM Form
  • Dose-Response Relationship, Drug
  • Glutathione Peroxidase (metabolism)
  • Glutathione Reductase (metabolism)
  • Glutathione Transferase (metabolism)
  • Liver (chemistry, enzymology)
  • Male
  • Muscular Atrophy (metabolism, veterinary)
  • Nutritional Requirements
  • Nutritional Status
  • Oxidation-Reduction
  • Poultry Diseases (metabolism)
  • Selenium (administration & dosage, blood, deficiency)
  • Turkeys (growth & development, metabolism)

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