Abstract |
We investigated in 51 consecutive outpatients with symptomatic congestive heart failure caused by abnormal left ventricular (LV) ejection fraction treated with furosemide or torsemide (10% also with metolazone), beta blockers, and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, 55% with spironolactone, and 18% with digoxin, the effects of doubling the dose of furosemide, torsemide, and metolazone on symptoms, weight, 6-minute walk distance, and echocardiographic measurements of LV systolic and diastolic function at 24 ± 6 days follow-up. At follow-up, the weight decreased from 70 ± 6 kg to 65 ± 6 kg (P < 0.001), the New York Heart Association functional class decreased from 2.9 ± 0.4 to 2.1 ± 0.2 (P < 0.001), the Minnesota With Heart Failure Questionnaire score decreased from 43 ± 7 to 28 ± 8 (P < 0.001), the 6-minute walk distance increased from 270 ± 46 m to 318 ± 44 m (P < 0.001), and there was no significant change in LV ejection fraction, LV end-diastolic dimension, LV end-systolic dimension, left atrial dimension, pulmonary artery systolic pressure, peak mitral early/ atrial ratio, mitral deceleration time, and velocity time interval. In conclusion, doubling the dose of diuretics in outpatients with symptomatic congestive heart failure caused a significant loss of weight and a significant improvement in symptoms and 6-minute walk distance but did not change LV systolic and diastolic function.
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Authors | Anil Kumar, Wilbert S Aronow, Aniket Vadnerkar, Kasturi Sivan, Sanjay Mittal |
Journal | American journal of therapeutics
(Am J Ther)
2009 Jan-Feb
Vol. 16
Issue 1
Pg. 5-7
ISSN: 1536-3686 [Electronic] United States |
PMID | 19142162
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Diuretics
- Digoxin
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Angiotensin Receptor Antagonists
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Diastole
- Digoxin
(therapeutic use)
- Diuretics
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Echocardiography
- Exercise Test
- Exercise Tolerance
- Female
- Follow-Up Studies
- Heart Failure
(drug therapy, physiopathology)
- Humans
- Male
- Middle Aged
- Outpatients
- Systole
- Ventricular Dysfunction, Left
(drug therapy, physiopathology)
- Walking
- Weight Loss
(drug effects)
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