Abstract | BACKGROUND AND OBJECTIVE: METHODS: An ischaemia/reperfusion model (3 and 2 h, respectively) was applied in 14 rabbits. Group S (n = 7) was infused with 0.9% NaCl (0.2 ml kg(-1) min(-1)) and group HES was infused with 6% HES 130/0.4 (0.2 ml kg(-1) min(-1)). The total liquid was divided into equal one-thirds and given in the preischaemia, ischaemia and reperfusion phases. Ketamine HCl (30 mg kg(-1)) was used for anaesthesia, and blood pressure, pulse and blood gases were monitored. Muscle biopsies were taken in the preischaemic (A), ischaemic (B) and reperfusion (C) phases. In these samples, nitrite, nitrate, reduced glutathione (GSH) and myeloperoxidase (MPO) were measured to assess oxidative stress elements, and malondialdehyde (MDA) was measured to assess lipid peroxidation. Repeated variance analysis, Mann-Whitney U test and Student's t test were used for statistical analysis of these parameters. RESULTS: In group S, the MPO levels were significantly increased in the reperfusion phase compared with baseline, whereas there was a decrease in MPO levels in the reperfusion period in the HES group. This difference between groups was statistically significant (P = 0.011). CONCLUSION:
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Authors | Nurten Inan, Serkan Iltar, Hatice Surer, Gulsen Yilmaz, K Bahadir Alemdaroglu, M Akif Yazar, Hulya Basar |
Journal | European journal of anaesthesiology
(Eur J Anaesthesiol)
Vol. 26
Issue 2
Pg. 160-5
(Feb 2009)
ISSN: 1365-2346 [Electronic] England |
PMID | 19142092
(Publication Type: Journal Article)
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Chemical References |
- Hydroxyethyl Starch Derivatives
- Peroxidase
|
Topics |
- Animals
- Disease Models, Animal
- Hydroxyethyl Starch Derivatives
(therapeutic use)
- Muscle, Skeletal
(drug effects, metabolism)
- Peroxidase
(metabolism)
- Rabbits
- Reperfusion Injury
(drug therapy, metabolism)
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