Leukocyte-endothelial interactions in pial arterioles and venules on development of cerebral ischemia in rats.

In vivo microscopy was used to study the interaction between leukocytes and the pial venular and arteriolar endothelium in rats during cerebral ischemia evoked by bilateral ligation occlusion of the carotid arteries. Specimens were obtained from 40 arterioles and 30 venules (diameter up to 40 micron) of the pia mater from Wistar rats (n = 7) subjected to ischemia for 5 h to respiratory arrest. The experimental data demonstrated significant differences in changes in the adhesion of leukocytes to the endothelium of arterial and venous microvessels during the development of hypoxia.
AuthorsN N Mel'nikova
JournalNeuroscience and behavioral physiology (Neurosci Behav Physiol) Vol. 39 Issue 2 Pg. 167-71 (Feb 2009) ISSN: 0097-0549 [Print] United States
PMID19140002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
  • Animals
  • Arterioles (metabolism, pathology, physiopathology)
  • Brain (blood supply, metabolism, pathology, physiopathology)
  • Brain Ischemia (metabolism, pathology, physiopathology)
  • Cell Adhesion
  • Endothelium, Vascular (metabolism, pathology, physiopathology)
  • Leukocytes (metabolism, pathology)
  • Male
  • Rats
  • Time Factors
  • Venules (metabolism, pathology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: