Abstract | BACKGROUND: METHODS: RESULTS: Study group patients vs controls had more frequent return of spontaneous circulation (39 of 48 patients [81%] vs 27 of 52 [52%]; P = .003) and improved survival to hospital discharge (9 [19%] vs 2 [4%]; P = .02). Study group patients with postresuscitation shock vs corresponding controls had improved survival to hospital discharge (8 of 27 patients [30%] vs 0 of 15 [0%]; P = .02), improved hemodynamics and central venous oxygen saturation, and more organ failure-free days. Adverse events were similar in the 2 groups. CONCLUSION: TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00411879.
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Authors | Spyros D Mentzelopoulos, Spyros G Zakynthinos, Maria Tzoufi, Nikos Katsios, Androula Papastylianou, Sotiria Gkisioti, Anastasios Stathopoulos, Androniki Kollintza, Elissavet Stamataki, Charis Roussos |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 169
Issue 1
Pg. 15-24
(Jan 12 2009)
ISSN: 1538-3679 [Electronic] United States |
PMID | 19139319
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasopressins
- Methylprednisolone
- Epinephrine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cardiopulmonary Resuscitation
(methods)
- Cause of Death
- Confidence Intervals
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Therapy, Combination
- Emergency Service, Hospital
- Epinephrine
(administration & dosage)
- Female
- Follow-Up Studies
- Heart Arrest
(drug therapy, mortality, therapy)
- Hospital Mortality
(trends)
- Hospitalization
- Humans
- Infusions, Intravenous
- Intensive Care Units
- Kaplan-Meier Estimate
- Male
- Methylprednisolone
(administration & dosage)
- Middle Aged
- Probability
- Proportional Hazards Models
- Prospective Studies
- Reference Values
- Risk Assessment
- Survival Rate
- Treatment Outcome
- Vasopressins
(administration & dosage)
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