Abstract |
In this paper, the cytotoxicity of EGCG against PC-3 prostate cancer cells and its molecular mechanism in the presence and absence of Zn2+ in vitro were investigated. The results showed that both EGCG and Zn2+ suppressed clonegenecity of PC-3 cells, and the suppression effect was enhanced in the coexist system of EGCG and Zn2+. MMP-9 is thought to play a significant role in cancer cell migration and invasion. In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.
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Authors | Lan Cui Zhang, Sheng Rong Shen, Shi Li Sun, Jun Guo Yang, Guo Qing He, Hai Ning Yu |
Journal | Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology
(Fen Zi Xi Bao Sheng Wu Xue Bao)
Vol. 41
Issue 6
Pg. 443-9
(Dec 2008)
ISSN: 1673-520X [Print] China |
PMID | 19137815
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Catechin
- epigallocatechin gallate
- Matrix Metalloproteinase 9
- Zinc
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Topics |
- Catechin
(analogs & derivatives, pharmacology)
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Humans
- Immunohistochemistry
- Male
- Matrix Metalloproteinase 9
(metabolism)
- Prostatic Neoplasms
(drug therapy, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Zinc
(pharmacology)
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