HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Growth inhibition of prostate cancer cells by epigallocatechin-3-gallate in the presence of Zn2+ in vitro].

Abstract
In this paper, the cytotoxicity of EGCG against PC-3 prostate cancer cells and its molecular mechanism in the presence and absence of Zn2+ in vitro were investigated. The results showed that both EGCG and Zn2+ suppressed clonegenecity of PC-3 cells, and the suppression effect was enhanced in the coexist system of EGCG and Zn2+. MMP-9 is thought to play a significant role in cancer cell migration and invasion. In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.
AuthorsLan Cui Zhang, Sheng Rong Shen, Shi Li Sun, Jun Guo Yang, Guo Qing He, Hai Ning Yu
JournalFen zi xi bao sheng wu xue bao = Journal of molecular cell biology (Fen Zi Xi Bao Sheng Wu Xue Bao) Vol. 41 Issue 6 Pg. 443-9 (Dec 2008) ISSN: 1673-520X [Print] China
PMID19137815 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Catechin
  • epigallocatechin gallate
  • Matrix Metalloproteinase 9
  • Zinc
Topics
  • Catechin (analogs & derivatives, pharmacology)
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Humans
  • Immunohistochemistry
  • Male
  • Matrix Metalloproteinase 9 (metabolism)
  • Prostatic Neoplasms (drug therapy, metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Zinc (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: