Osteoblastoma response to chemotherapy.

Abstract

An 8-year-old boy had an osteoblastoma of the body of C2. After attempted excision, the tumor recurred rapidly and massively. The tumor shrank progressively after treatment with high-dose methotrexate, doxorubicin, and cisplatin. The patient has stopped treatment and been stable for 33 months. Surgical excision remains the treatment of choice for osteoblastoma. Chemotherapy may be useful in selected patients with a recurrent, aggressive tumor or in patients with surgically inaccessible disease.

• Authors: B Camitta, R Wells, A Segura, K K Unni, K Murray, D Dunn
• Journal: Cancer (Cancer) Vol. 68 Issue 5 Pg. 999-1003 (Sep 01 1991) ISSN: 0008-543X [Print] United States
• PMID: 1913494 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Methotrexate

Topics

• Bone Neoplasms (drug therapy)
• Cervical Vertebrae
• Child
• Dose-Response Relationship, Drug
• Head and Neck Neoplasms (drug therapy)
• Humans
• Male
• Methotrexate (therapeutic use)
• Osteoma, Osteoid (drug therapy)