Abstract | OBJECTIVE: METHODS: Six hundred and sixty-six patients with above mentioned conditions and diagnosed as IFI from January, 2007 to July, 2007 were enrolled. Intravenous itraconazole was administered at a dose of 200 mg every 12 hours for 2 days and followed by 200 mg every 24 hours. Patients were then switched to oral itraconazole according to the clinical situation. Responses were determined on the basis of clinical and microbiological criteria. RESULTS: The probability of defervescence was 69.8% and the total response rates among related to itraconazole were the proven, probable and possible IFI patients were 73.7%, 68.1% and 68.2% (P = 0.380). Adverse effects were found in 58 patients (8.7%), which were mainly mild to medium reversible dysfunction of liver and gastrointestinal tract. CONCLUSION:
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Authors | Yu Ji, Xiao-jun Huang |
Journal | Zhonghua nei ke za zhi
(Zhonghua Nei Ke Za Zhi)
Vol. 47
Issue 12
Pg. 1022-5
(Dec 2008)
ISSN: 0578-1426 [Print] China |
PMID | 19134309
(Publication Type: English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- Antifungal Agents
- Itraconazole
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antifungal Agents
(adverse effects, therapeutic use)
- Child
- Female
- Hematologic Diseases
(complications, microbiology)
- Hematopoietic Stem Cell Transplantation
- Humans
- Itraconazole
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Mycoses
(complications, drug therapy)
- Retrospective Studies
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