Intralesional injection of Pingyangmycin may be an effective treatment for epulis.

Abstract

Gingival epulis represents a family of benign tumors and tumorlike masses of the gingiva. A spectrum of inflammatory and other reactive changes can be observed pathologically as granulation, fibrous or vascular tissue. It may occur at any age, but most commonly found in patients at their twenties and sixties. Women are more frequently affected than men. Surgical excision or removal is the treatment of choice, and wider resection including extraction of the involved teeth and adjacent tissues is often required in order to prevent recurrence. However, wider resection may result in cosmetic and functional problems. Epulis bears some similarities with hemangioma both clinically and histopathologically. Therefore, we hypothesize that intralesional injection of Pingyangmycin may be a safe and effective treatment for epulis. The efficacy of this treatment modality is worthy of further investigation.

• Authors: Jia Wei Zheng, Qin Zhou, Xiu Juan Yang, Yue He, Yan An Wang, Wei Min Ye, Han Guang Zhu, Zhi Yuan Zhang
• Journal: Medical hypotheses (Med Hypotheses) Vol. 72 Issue 4 Pg. 453-4 (Apr 2009) ISSN: 0306-9877 [Print] United States
• PMID: 19131174 (Publication Type: Journal Article)

Chemical References

• Bleomycin
• bleomycetin

Topics

• Bleomycin (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Gingival Neoplasms (drug therapy)
• Humans
• Injections, Intralesional
• Male