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A poly-herbal formulation accelerates normal and impaired diabetic wound healing.

Abstract
In the present study, a poly-herbal formulation (PHF) was prepared by combining the aqueous lyophilized leaf extracts of Hippophae rhamnoides L. and Aloe vera L. and the ethanol rhizome extract of Curcuma longa L., in an optimized ratio (1 : 7 : 1). The efficacy of PHF treatment was studied in normal and impaired diabetic rats using a full-thickness cutaneous wound model. Topical PHF treatment increased cellular proliferation and collagen synthesis at the wound site in normal rats, as evidenced by the significant increase in DNA, total protein, hydroxyproline, and hexosamine contents in comparison with a positive control treated with a povidone-iodine ointment. The histological examinations and matrix metalloproteinases expression also correlated well with the biochemical findings, confirming the efficacy of PHF in normal wounds. In the streptozotocin-induced diabetic rats, PHF treatment increased hydroxyproline and hexosamine content. A faster wound contraction was also observed in PHF-treated normal and diabetic rats. The PHF also promoted angiogenesis as evidenced by an in vitro chick chorioallantoic membrane model and in vivo up-regulated vascular endothelial growth factor expression. The results suggest that PHF possesses significant wound healing potential in both normal as well as chronic diabetic wounds.
AuthorsAsheesh Gupta, Nitin K Upadhyay, R C Sawhney, Ratan Kumar
JournalWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (Wound Repair Regen) 2008 Nov-Dec Vol. 16 Issue 6 Pg. 784-90 ISSN: 1524-475X [Electronic] United States
PMID19128249 (Publication Type: Journal Article)
Chemical References
  • Plant Extracts
Topics
  • Aloe
  • Animals
  • Curcuma
  • Diabetes Complications (drug therapy)
  • Hippophae
  • Male
  • Phytotherapy
  • Plant Extracts (therapeutic use)
  • Rats
  • Rats, Sprague-Dawley
  • Skin Ulcer (drug therapy)
  • Time Factors
  • Wound Healing

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