Obesity and activated protein C resistance.

Abstract

It has been reported that obesity may be associated with activated protein C resistance, which could increase the thrombotic risk in these patients. The aim of our study was to evaluate this parameter in obese patients and controls, as well as the effect of weight loss on this parameter. In 63 severely or morbidly obese patients and in 65 healthy volunteers, an anthropometric and analytical evaluation (activated protein C resistance and prothrombin fragment F1 + 2) was performed at baseline and after 3 months of diet. Obese patients showed higher levels of F1 + 2 than controls, whereas activated protein C sensitivity ratios showed no differences. After weight loss, prothrombin fragment F1 + 2 was reduced, but no differences were found in activated protein C sensitivity. We did not find an activated protein C-resistant phenotype in obese subjects.

• Authors: Eva Solá, Amparo Vayá, Piedad Villa, Francisco España, Amparo Estellés, Katherinne García, Antonio Hernández-Mijares
• Journal: Pathophysiology of haemostasis and thrombosis (Pathophysiol Haemost Thromb) Vol. 36 Issue 2 Pg. 64-8 ( 2008) ISSN: 1424-8840 [Electronic] Switzerland
• PMID: 19127084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• Peptide Fragments
• prothrombin fragment 1.2
• Prothrombin

Topics

• Activated Protein C Resistance (blood)
• Adult
• Case-Control Studies
• Female
• Humans
• Male
• Middle Aged
• Obesity (blood, complications)
• Obesity, Morbid (blood, complications)
• Peptide Fragments (blood)
• Prothrombin
• Weight Loss
• Young Adult