Abstract | PURPOSE: METHODS: RESULTS: UGT8, CERK, and ST8SIA1 were associated with poor pathohistological grading (P < 0.001). High CERK expression was correlated with ErbB2 status (P = 0.006). Among ER positive breast cancers a significant worse prognosis for patients with tumors showing low ST8SIA1 and UGT8 expression was observed. In the ER negative subgroup those samples with high CERK expression displayed a worse prognosis. In a multivariate analysis only ST8SIA1 and tumor size remained significant. CONCLUSIONS:
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Authors | Eugen Ruckhäberle, Thomas Karn, Achim Rody, Lars Hanker, Regine Gätje, Dirk Metzler, Uwe Holtrich, Manfred Kaufmann |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 135
Issue 8
Pg. 1005-13
(Aug 2009)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 19125296
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- UGT8 protein, human
- Ganglioside Galactosyltransferase
- Sialyltransferases
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
- Phosphotransferases (Alcohol Group Acceptor)
- ceramide kinase
- Receptor, ErbB-2
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Topics |
- Adult
- Breast Neoplasms
(diagnosis, enzymology, genetics)
- Disease-Free Survival
- Female
- Ganglioside Galactosyltransferase
(genetics, metabolism)
- Gene Expression Regulation, Neoplastic
- Humans
- Middle Aged
- Phosphotransferases (Alcohol Group Acceptor)
(genetics, metabolism)
- Prognosis
- Receptor, ErbB-2
(genetics, metabolism)
- Sialyltransferases
(genetics, metabolism)
- Tissue Array Analysis
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