Adolescent wilms tumor with intraspinal and bone metastases: a case report and the review of literature.

Abstract

A 14-year-old girl was referred for a large tumor of the left kidney, with intraspinal and vertebral metastases. Left nephrectomy and intraspinal tumor resection were performed. The histology of both tumors was nephroblastoma with no anaplasia and favorable histology, and they were diagnosed as stage IV. The tumor bed and vertebras were irradiated. We started chemotherapy according to the DD-4A regimen of Japanese Wilms' Tumor Study Group. The vertebral metastasis was additionally irradiated. The patient has remained in disease-free remission for 45 months after the surgical resection. Intensive multimodality therapy including DD-4A regimen of National Wilms' Tumor Study can result in long-term disease-free remission.

• Authors: Reina Watanabe, Atsushi Takahashi, Makoto Suzuki, Fumiaki Toki, Takashi Kanazawa, Junko Hirato, Akihiro Morikawa, Hiroyuki Kuwano
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 31 Issue 1 Pg. 45-8 (Jan 2009) ISSN: 1536-3678 [Electronic] United States
• PMID: 19125087 (Publication Type: Case Reports, Journal Article)

Topics

• Adolescent
• Bone Neoplasms (secondary, therapy)
• Combined Modality Therapy
• Female
• Humans
• Kidney Neoplasms (pathology, therapy)
• Magnetic Resonance Imaging
• Neoplasm Staging
• Spinal Neoplasms (secondary, therapy)
• Wilms Tumor (secondary, therapy)