Abstract | CONTEXT: OBJECTIVE: To determine if impaired cognitive status, older age, apolipoprotein E-4 (APOE-4) genetic risk for Alzheimer disease, family history of dementia, and less education are associated with increased regional cerebral FDDNP-PET binding. DESIGN: Cross-sectional clinical study. SETTING: A university research institute. PARTICIPANTS: Volunteer sample of 76 middle-aged and older persons without dementia (mean age, 67 years) including 36 with mild cognitive impairment. Of the 72 subjects with genetic data, 34 were APOE-4 carriers. MAIN OUTCOME MEASURES: The FDDNP-PET signal in brain regions of interest, including medial and lateral temporal, posterior cingulate, parietal, and frontal. RESULTS: For all regions studied, cognitive status was associated with increased FDDNP binding (P < .02 to .005). Older age was associated with increased lateral temporal FDDNP binding. Carriers of APOE-4 demonstrated higher frontal FDDNP binding than noncarriers. In the mild cognitive impairment group, age was associated with increased medial and lateral temporal FDDNP binding, and APOE-4 carriers had higher medial temporal binding than noncarriers. CONCLUSIONS: Impaired cognitive status, older age, and APOE-4 carrier status are associated with increased brain FDDNP-PET binding in persons without dementia, consistent with previous clinical and postmortem studies associating these risk factors with amyloid plaque and tau tangle accumulation. Stratifying subject groups according to APOE-4 carrier status, age, and cognitive status may therefore be an informative strategy in future clinical trials using FDDNP-PET.
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Authors | Gary W Small, Prabha Siddarth, Alison C Burggren, Vladimir Kepe, Linda M Ercoli, Karen J Miller, Helen Lavretsky, Paul M Thompson, Greg M Cole, S C Huang, Michael E Phelps, Susan Y Bookheimer, Jorge R Barrio |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 66
Issue 1
Pg. 81-7
(Jan 2009)
ISSN: 1538-3636 [Electronic] United States |
PMID | 19124691
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- 2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile
- Apolipoprotein E4
- MAPT protein, human
- Nitriles
- tau Proteins
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Topics |
- Aged
- Alleles
- Alzheimer Disease
(diagnostic imaging, genetics)
- Apolipoprotein E4
(genetics)
- Cerebral Cortex
(diagnostic imaging)
- Cognition Disorders
(diagnostic imaging, genetics)
- Educational Status
- Female
- Genetic Predisposition to Disease
(genetics)
- Humans
- Male
- Middle Aged
- Neurofibrillary Tangles
(diagnostic imaging)
- Neuropsychological Tests
- Nitriles
- Plaque, Amyloid
(diagnostic imaging)
- Positron-Emission Tomography
- Risk Factors
- tau Proteins
(metabolism)
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