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TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma.

AbstractBACKGROUND:
Transforming growth factor-alpha (TGF-alpha), a stimulatory growth factor and member of the epidermal growth factor family, is a mediator of oncogenesis and malignant progression in colorectal carcinogenesis. Limited evidence suggests its utility as a growth-related biomarker of risk for colorectal cancer.
METHODS:
We measured expression of TGF-alpha in biopsies of normal-appearing colorectal mucosa using automated immunohistochemistry and quantitative image analysis in a subsample of 29 cases and 31 controls from a colonoscopy-based case-control study (n = 203) of biomarkers of risk for incident sporadic colorectal adenoma. Diet, lifestyle, and medical history were assessed with validated questionnaires.
RESULTS:
TGF-alpha expression in the rectum was 51% higher in cases compared with controls (P = 0.05) and statistically significantly associated with accepted risk factors for colorectal neoplasms (36% lower among nonsteroidal anti-inflammatory drug users, 49% lower among women using hormone replacement therapy, 79% higher among persons with a family history of colorectal cancer).
CONCLUSIONS:
TGF-alpha expression in the normal-appearing rectal mucosa shows promise as an early, potentially modifiable biomarker of risk for colorectal cancer.
AuthorsCarrie R Daniel, Roberd M Bostick, William Dana Flanders, Qi Long, Veronika Fedirko, Eduard Sidelnikov, March E Seabrook
JournalCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 18 Issue 1 Pg. 65-73 (Jan 2009) ISSN: 1055-9965 [Print] United States
PMID19124482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Transforming Growth Factor alpha
Topics
  • Adenoma (epidemiology, metabolism, pathology)
  • Adult
  • Aged
  • Biomarkers, Tumor (metabolism)
  • Case-Control Studies
  • Chi-Square Distribution
  • Colonoscopy
  • Colorectal Neoplasms (epidemiology, metabolism, pathology)
  • Diet
  • Female
  • Humans
  • Immunohistochemistry
  • Incidence
  • Intestinal Mucosa (metabolism, pathology)
  • Male
  • Middle Aged
  • Phenotype
  • Regression Analysis
  • Risk Factors
  • Surveys and Questionnaires
  • Transforming Growth Factor alpha (metabolism)

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