Abstract | BACKGROUND: METHODS: We measured expression of TGF-alpha in biopsies of normal-appearing colorectal mucosa using automated immunohistochemistry and quantitative image analysis in a subsample of 29 cases and 31 controls from a colonoscopy-based case-control study (n = 203) of biomarkers of risk for incident sporadic colorectal adenoma. Diet, lifestyle, and medical history were assessed with validated questionnaires. RESULTS:
TGF-alpha expression in the rectum was 51% higher in cases compared with controls (P = 0.05) and statistically significantly associated with accepted risk factors for colorectal neoplasms (36% lower among nonsteroidal anti-inflammatory drug users, 49% lower among women using hormone replacement therapy, 79% higher among persons with a family history of colorectal cancer). CONCLUSIONS:
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Authors | Carrie R Daniel, Roberd M Bostick, William Dana Flanders, Qi Long, Veronika Fedirko, Eduard Sidelnikov, March E Seabrook |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 18
Issue 1
Pg. 65-73
(Jan 2009)
ISSN: 1055-9965 [Print] United States |
PMID | 19124482
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Transforming Growth Factor alpha
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Topics |
- Adenoma
(epidemiology, metabolism, pathology)
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Case-Control Studies
- Chi-Square Distribution
- Colonoscopy
- Colorectal Neoplasms
(epidemiology, metabolism, pathology)
- Diet
- Female
- Humans
- Immunohistochemistry
- Incidence
- Intestinal Mucosa
(metabolism, pathology)
- Male
- Middle Aged
- Phenotype
- Regression Analysis
- Risk Factors
- Surveys and Questionnaires
- Transforming Growth Factor alpha
(metabolism)
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