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Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats.

AbstractOBJECTIVE:
To evaluate the efficacy of the fluoroquinolone pradofloxacin in the treatment of cats experimentally infected with Mycoplasma hemofelis.
ANIMALS:
23 young adult specific-pathogen-free cats.
PROCEDURES:
Cats were inoculated with M hemofelis from a chronically infected donor and assigned to 1 of 4 treatment groups: a doxycycline group, a low-dose-pradofloxacin group, a high-dose-pradofloxacin group, and an untreated control group. Treatment was initiated for 14 days when M hemofelis infection was detected via PCR assay and clinical signs of hemoplasmosis were present. Cats that had negative PCR assay results after treatment were administered a glucocorticoid and monitored via PCR assay for an additional 4 weeks.
RESULTS:
All cats yielded positive results for M hemofelis via conventional PCR and quantitative PCR assays and developed anemia. The low-dose-pradofloxacin group had significantly lower M hemofelis copy numbers than the doxycycline group. Six cats treated with pradofloxacin yielded negative results during treatment. Of those cats, 4 yielded negative conventional PCR assay results and all yielded negative quantitative PCR assay results for M hemofelis 1 month after administration of high-dose glucocorticoids.
CONCLUSIONS AND CLINICAL RELEVANCE:
Pradofloxacin had anti-M hemofelis effects similar to those of doxycycline. In addition, pradofloxacin may be more effective at long-term M hemofelis organism clearance than doxycycline.
AuthorsKristy L Dowers, Séverine Tasker, Steven V Radecki, Michael R Lappin
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 70 Issue 1 Pg. 105-11 (Jan 2009) ISSN: 0002-9645 [Print] United States
PMID19119955 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Fluoroquinolones
  • pradofloxacin
  • Doxycycline
Topics
  • Anemia (drug therapy, metabolism, microbiology, veterinary)
  • Animals
  • Anti-Bacterial Agents (pharmacokinetics, pharmacology)
  • Blood Cell Count (veterinary)
  • Cat Diseases (drug therapy, metabolism, microbiology)
  • Cats
  • DNA, Bacterial (chemistry, genetics)
  • Doxycycline (pharmacokinetics, pharmacology)
  • Female
  • Fluoroquinolones (pharmacokinetics, pharmacology)
  • Hematocrit (veterinary)
  • Male
  • Mycoplasma (genetics, growth & development)
  • Mycoplasma Infections (drug therapy, metabolism, microbiology, veterinary)
  • Polymerase Chain Reaction (veterinary)
  • Random Allocation
  • Specific Pathogen-Free Organisms

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