Abstract | OBJECTIVE: ANIMALS: 23 young adult specific-pathogen-free cats. PROCEDURES: Cats were inoculated with M hemofelis from a chronically infected donor and assigned to 1 of 4 treatment groups: a doxycycline group, a low-dose- pradofloxacin group, a high-dose- pradofloxacin group, and an untreated control group. Treatment was initiated for 14 days when M hemofelis infection was detected via PCR assay and clinical signs of hemoplasmosis were present. Cats that had negative PCR assay results after treatment were administered a glucocorticoid and monitored via PCR assay for an additional 4 weeks. RESULTS: All cats yielded positive results for M hemofelis via conventional PCR and quantitative PCR assays and developed anemia. The low-dose- pradofloxacin group had significantly lower M hemofelis copy numbers than the doxycycline group. Six cats treated with pradofloxacin yielded negative results during treatment. Of those cats, 4 yielded negative conventional PCR assay results and all yielded negative quantitative PCR assay results for M hemofelis 1 month after administration of high-dose glucocorticoids. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Kristy L Dowers, Séverine Tasker, Steven V Radecki, Michael R Lappin |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 70
Issue 1
Pg. 105-11
(Jan 2009)
ISSN: 0002-9645 [Print] United States |
PMID | 19119955
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- DNA, Bacterial
- Fluoroquinolones
- pradofloxacin
- Doxycycline
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Topics |
- Anemia
(drug therapy, metabolism, microbiology, veterinary)
- Animals
- Anti-Bacterial Agents
(pharmacokinetics, pharmacology)
- Blood Cell Count
(veterinary)
- Cat Diseases
(drug therapy, metabolism, microbiology)
- Cats
- DNA, Bacterial
(chemistry, genetics)
- Doxycycline
(pharmacokinetics, pharmacology)
- Female
- Fluoroquinolones
(pharmacokinetics, pharmacology)
- Hematocrit
(veterinary)
- Male
- Mycoplasma
(genetics, growth & development)
- Mycoplasma Infections
(drug therapy, metabolism, microbiology, veterinary)
- Polymerase Chain Reaction
(veterinary)
- Random Allocation
- Specific Pathogen-Free Organisms
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