[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].

Abstract

OBJECTIVE:

To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC).

METHOD:

The immunohistochemical technique was used to detect the expression of p53, p63 and p73 in 67 cases of NPSC, para-cancer tissues and non-cancer tissues.

RESULT:

The positive rate of p53 and p63 protein in NPSC was significantly higher than that in park cancer tissues and non-cancer tissues (P<0.01), and there were a positive correlation between the expression of p53 and p63 protein in NPSC (P<0.01). But the expression of p73 had no significant difference among NPSC, para-cancer tissues and non-cancer tissues (P>0.05).

CONCLUSION:

There are positive correlation between p53 and p63 protein in NPSC, and they may play an important role in the tumorgenesis of NPSC. The p73 may not be associated with tumorgenesis of NPSC.

• Authors: Tao Zhang, Haiying Jia, Jiqun Wang, Yanchun Shan, Sijin Luo, Zhi Tang
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 22 Issue 20 Pg. 919-21 (Oct 2008) ISSN: 2096-7993 [Print] China
• PMID: 19119599 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• DNA-Binding Proteins
• Nuclear Proteins
• TP63 protein, human
• TP73 protein, human
• Trans-Activators
• Transcription Factors
• Tumor Protein p73
• Tumor Suppressor Protein p53
• Tumor Suppressor Proteins

Topics

• Carcinoma, Squamous Cell (metabolism, pathology)
• DNA-Binding Proteins (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Nose Neoplasms (metabolism, pathology)
• Nuclear Proteins (metabolism)
• Paranasal Sinus Neoplasms (metabolism, parasitology)
• Trans-Activators (metabolism)
• Transcription Factors
• Tumor Protein p73
• Tumor Suppressor Protein p53 (metabolism)
• Tumor Suppressor Proteins (metabolism)