Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: We found that anoxia/ hypoxia significantly alters the responsiveness of glioblastoma multiforme cells to DT-IL13QM. Interestingly, bringing these cells back to normoxia caused them to become even more susceptible to the cytotoxin than the cells maintained under normoxia. Anoxia/ hypoxia caused a highly prominent decrease in the immunoreactive levels of both IL-13R and active forms of furin, and reoxygenation not only restored their levels but also became higher than that in normoxic glioblastoma multiforme cells. CONCLUSIONS:
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Authors | Tie Fu Liu, Jiaozhong Cai, Denise M Gibo, Waldemar Debinski |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 15
Issue 1
Pg. 160-8
(Jan 01 2009)
ISSN: 1078-0432 [Print] United States |
PMID | 19118043
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Cytotoxins
- Diphtheria Toxin
- Immunotoxins
- Interleukin-13
- Interleukin-13 Receptor alpha2 Subunit
- Furin
- Oxygen
|
Topics |
- Brain Neoplasms
(metabolism, therapy)
- Cell Hypoxia
- Cell Line, Tumor
- Cytotoxins
(pharmacology)
- Diphtheria Toxin
(pharmacology)
- Furin
(analysis)
- Glioblastoma
(metabolism, therapy)
- Humans
- Immunotoxins
(pharmacology)
- Interleukin-13
- Interleukin-13 Receptor alpha2 Subunit
(metabolism)
- Oxygen
(pharmacology)
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