Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response.
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| Abstract |
Progressive degeneration of striatal projection neurons is thought to account for the loss of L-Dopa response observed in the majority of patients with the parkinsonian variant of multiple system atrophy (MSA-P). Here we have investigated the effects of E14 embryonic striatal allografts on dopaminergic responsiveness in the unilateral double-lesion rat model of MSA-P by using tests of complex motor behavior. Both sham and graft animals showed an increase in apomorphine-induced rotations as well as an improvement in cylinder test performance following surgical intervention. In contrast, L-Dopa responsiveness of stepping behavior was improved only in grafted animals. The restoration of apomorphine-induced rotation correlated with the P-zone volume of grafts. Our findings indicate that transplantation of embryonic striatal grafts might, at least to some extent, restore responsiveness to L-Dopa in tasks of complex motor behavior. Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response.
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| Authors | Martin Köllensperger, Nadia Stefanova, Anton Pallua, Zoe Puschban, Georg Dechant, Monika Hainzer, Markus Reindl, Werner Poewe, Guido Nikkhah, Gregor K Wenning |
| Journal | Journal of neuroscience research (J Neurosci Res) Vol. 87 Issue 7 Pg. 1679-85 (May 15 2009) ISSN: 1097-4547 [Electronic] United States |
| PMID | 19115416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright 2008 Wiley-Liss, Inc. |
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