Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer.

Abstract	Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene in several solid tumors. The role of BRMS1 in non-small cell lung cancer (NSCLC) is not well established. To assess in vitro and in vivo metastatic behavior H1299 NSCLC cells stably expressing BRMS1 or a vector control were created. BRMS1 expression significantly decreases both migration and invasion of NSCLC cells in vitro. Importantly, in flank xenografts, BRMS1 suppresses the formation of pulmonary and hepatic metastases but does not significantly affect primary tumor growth. To evaluate whether BRMS1 is related to the progression of NSCLC, we examined BRMS1 expression in human NSCLC. Both BRMS1 mRNA and protein levels are diminished in NSCLC compared to adjacent non-cancerous lung. BRMS1 expression is also lower in squamous cell carcinoma compared to adenocarcinoma. Moreover, preservation of tumor BRMS1 expression is associated with improved patient survival. Thus, BRMS1 functions as a metastasis suppressor and may be a prognostic indicator for human NSCLC.
Authors	Philip W Smith, Yuan Liu, Suzanne A Siefert, Christopher A Moskaluk, Gina R Petroni, David R Jones
Journal	Cancer letters (Cancer Lett) Vol. 276 Issue 2 Pg. 196-203 (Apr 18 2009) ISSN: 1872-7980 [Electronic] Ireland
PMID	19111386 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	BRMS1 protein, human Neoplasm Proteins RNA, Messenger Repressor Proteins
Topics	Aged Animals Carcinoma, Non-Small-Cell Lung (mortality, pathology) Cell Line, Tumor Cell Movement Female Humans Lung Neoplasms (mortality, pathology) Male Mice Middle Aged Neoplasm Invasiveness Neoplasm Metastasis (prevention & control) Neoplasm Proteins (analysis, genetics, physiology) RNA, Messenger (analysis) Repressor Proteins Smoking (metabolism)

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