Generalized eruptive keratoacanthomas of Grzybowski treated with isotretinoin.

Abstract

Generalized eruptive keratoacanthomas of Grzybowski is a rare condition of unknown etiology. The disease is characterized by the abrupt onset of many small crateriform papules on the skin and mucous membranes. The authors report of a man with multiple eruptive keratoacanthomas of Grzybowski who responded favorably to oral isotretinoin therapy. After 2 years of follow-up, a complete regression of all lesions was observed, and this rapid clearance under isotretinoin therapy is intriguing with regard to the possible etiology of the condition.

• Authors: Travis Vandergriff, Krystal Nakamura, Whitney A High
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 7 Issue 11 Pg. 1069-71 (Nov 2008) ISSN: 1545-9616 [Print] United States
• PMID: 19110739 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratolytic Agents
• Isotretinoin

Topics

• Humans
• Isotretinoin (therapeutic use)
• Keratinocytes (drug effects, pathology)
• Keratoacanthoma (drug therapy, pathology)
• Keratolytic Agents (therapeutic use)
• Male
• Middle Aged
• Skin (pathology)