Immunoglobulin allotypes in systemic lupus erythematosus--results of a central European multicenter study. SLE Study Group.

Abstract

Immunoglobulin heavy chains (G1m, G2m, G3m, A2m) and kappa light chain (Km) allotype and phenotype frequencies were examined in 323 central European Caucasian patients with systemic lupus erythematosus (SLE). No significant differences were found between the different allotype or phenotype frequencies of the SLE patients and a control group of healthy individuals. Our results indicate that Gm, A2m and Km allotypes do not represent susceptibility factors for SLE in Caucasians.

• Authors: K Hartung, R Coldewey, E Röther, K Pirner, C Specker, H H Peter, J R Kalden, H J Lakomek, H Deicher, G G de Lange
• Journal: Experimental and clinical immunogenetics (Exp Clin Immunogenet) Vol. 8 Issue 1 Pg. 11-5 ( 1991) ISSN: 0254-9670 [Print] Switzerland
• PMID: 1910857 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin A
• Immunoglobulin Allotypes
• Immunoglobulin Gm Allotypes
• Immunoglobulin Km Allotypes

Topics

• Gene Frequency
• Humans
• Immunoglobulin A (genetics)
• Immunoglobulin Allotypes (genetics)
• Immunoglobulin Gm Allotypes (genetics)
• Immunoglobulin Km Allotypes (genetics)
• Lupus Erythematosus, Systemic (genetics, immunology)
• Phenotype
• White People