[Efficacy of vaccination against hepatitis A in HIV infected adults from Lodz region--preliminary report].

Abstract

OBJECTIVE:

To estimate the prevalence of anti-HAV-T in the group of HIV-positive adults and to assess the efficacy of vaccination against viral hepatitis A.

MATERIAL AND METHODS:

In HIV-infected outpatients anti-HAV-T was determined (electrochemiluminescence method). Patients susceptible to HAV infection were qualified for vaccination.

RESULTS:

In the group of 175 HIV-infected patients, 70 persons (40%) were anti-HAV-T positive. Prevalence of anti-HAV-T was significantly higher in patients over 35 years of age. Anti-HAV-T were present in all individuals older than 50 years. So far 47 patients have completed vaccination. Good response (detectable anti-HAV-T 1 month after booster dose) was obtained in 73,0% patients. Individuals with actual CD4 count above 200 cells/ul responded better (81,2%) than persons with CD4 count 200 cells/ul or lower (20%). Nadir CD4 count above 50 cells/ul predicted better response than 50 cells/ul or below (78,8% and 25% respectively). One year after vaccination anti-HAV-T were still detectable in 21 patients (56,8%).

CONCLUSIONS:

1. Most of studied HIV-positive patients (60%) were susceptible to HAV infection and should be vaccinated. 2. Good response to vaccination was obtained in 73% of patients and it was higher in persons with actual CD4 count above 200 cells/ul and nadir CD4 count above 50 cells/ul.

• Authors: Elzbieta Jabłonowska, Jan Kuydowicz, Ewa Małolepsza
• Journal: Przeglad epidemiologiczny (Przegl Epidemiol) Vol. 62 Issue 3 Pg. 605-12 ( 2008) ISSN: 0033-2100 [Print] Poland
• Vernacular Title: Ocena skuteczności szczepienia przeciwko wirusowemu zapaleniu watroby typu A w grupie dorosłych osób zakazonych HIV z regionu łódzkiego--doniesienie wstepne.
• PMID: 19108525 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hepatitis A Antibodies
• Hepatitis A Vaccines

Topics

• Adult
• HIV Infections (immunology, virology)
• Hepatitis A (prevention & control)
• Hepatitis A Antibodies (biosynthesis, blood)
• Hepatitis A Vaccines (administration & dosage)
• Humans
• Male
• Middle Aged
• Poland (epidemiology)
• Prevalence
• Severity of Illness Index
• Virus Replication (drug effects)