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Apoptosis inducement of bigelovin from Inula helianthus-aquatica on human Leukemia U937 cells.

Abstract
Inula helianthus-aquatica C. Y. Wu is a traditional medicinal plant used to treat some cancers in folk herbal medicine of Yunnan, China. Bigelovin, a sesquiterpene lactone isolated from this herb, potently inhibits the growth of a panel of eight cancer cell lines, especially in human monoblastic leukemia U937 cells with an IC(50) value of 0.47 microM. Characteristic morphological features of apoptosis were observed in U937 cells treated with bigelovin. Annexin V and nuclear DNA content distribution assays showed that the percentage of Annexin V positive cells increased to 8.86% (24 h) with 1 microM bigelovin treatment, and cells treated with bigelovin at this concentration apparently arrested at G(0)/G(1) phase compared with the control. These data suggested that cytotoxic effect of bigelovin on U937 cells involves induction of apoptosis, and the cell cycle is arrested at G(0)/G(1) phase.
AuthorsGuang-Zhi Zeng, Ning-Hua Tan, Chang-Jiu Ji, Jun-Ting Fan, Huo-Qiang Huang, Hong-Jin Han, Guang-Biao Zhou
JournalPhytotherapy research : PTR (Phytother Res) Vol. 23 Issue 6 Pg. 885-91 (Jun 2009) ISSN: 1099-1573 [Electronic] England
PMID19107858 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright(c) 2008 John Wiley & Sons, Ltd.
Chemical References
  • Annexin A5
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Lactones
  • Sesquiterpenes
  • bigelovin
Topics
  • Annexin A5
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Apoptosis (drug effects)
  • Cell Cycle (drug effects)
  • Cell Proliferation
  • Drugs, Chinese Herbal (pharmacology)
  • Humans
  • Inula (chemistry)
  • Lactones (pharmacology)
  • Sesquiterpenes (pharmacology)
  • U937 Cells

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